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Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea / 결핵
Tuberculosis and Respiratory Diseases ; : 348-356, 2019.
Article in English | WPRIM | ID: wpr-761956
ABSTRACT

BACKGROUND:

Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients.

METHODS:

Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed.

RESULTS:

Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01–7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of 3.3±2.8 years post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%).

CONCLUSION:

Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Comorbidity / Mass Screening / Medical Records / Survival Rate / Retrospective Studies / Follow-Up Studies / Heart-Lung Transplantation / Lung Transplantation / Diabetes Mellitus / Renal Insufficiency, Chronic Type of study: Observational study / Prognostic study / Screening study Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: Tuberculosis and Respiratory Diseases Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Comorbidity / Mass Screening / Medical Records / Survival Rate / Retrospective Studies / Follow-Up Studies / Heart-Lung Transplantation / Lung Transplantation / Diabetes Mellitus / Renal Insufficiency, Chronic Type of study: Observational study / Prognostic study / Screening study Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: Tuberculosis and Respiratory Diseases Year: 2019 Type: Article