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MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage
Yonsei Medical Journal ; : 774-781, 2019.
Article in English | WPRIM | ID: wpr-762107
ABSTRACT

PURPOSE:

Cerebral small vessel disease (SVD) is known to be associated with ischemic stroke, intracerebral hemorrhage (ICH), and cognitive impairment. In this retrospective observational study, we explored SVD markers on MRI relevant to spontaneous ICH. MATERIALS AND

METHODS:

The ICH group consisted of 150 consecutive patients with a first primary parenchymal ICH, and the control group consisted of 271 age- and sex-matched individuals who underwent brain MRI in a health care center. We compared cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular space (EPVS), and lacunae in the ICH and control groups.

RESULTS:

A total of 1278 CMB lesions were identified in 121 of the 150 patients in the ICH group (80.6%), while 77 CMB lesions were found in 32 of the 271 individuals in the control group (11.8%). WMH and EPVS were more severe and lacunae were more frequent in the ICH patients than in the control group. When receiver operating characteristic (ROC) curves were plotted, number of CMBs most significantly predicted ICH. All imaging markers were significantly associated with ICH in every age group. The location of CMBs coincided with the location of ICH, and ICH volume correlated with CMB count.

CONCLUSION:

All MRI markers for SVD were worse in ICH patients than in healthy controls, and these markers were prominent even in young ICH patients. Lacunae, WMH, EPVS, and CMB should be considered as factors related with spontaneous ICH.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Brain / Magnetic Resonance Imaging / Cerebral Hemorrhage / Retrospective Studies / ROC Curve / Cerebral Amyloid Angiopathy / Cognition Disorders / Stroke / Intracranial Hemorrhages / Delivery of Health Care Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Brain / Magnetic Resonance Imaging / Cerebral Hemorrhage / Retrospective Studies / ROC Curve / Cerebral Amyloid Angiopathy / Cognition Disorders / Stroke / Intracranial Hemorrhages / Delivery of Health Care Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 2019 Type: Article