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Emerging Therapies in Chronic Spontaneous Urticaria
Allergy, Asthma & Immunology Research ; : 470-481, 2019.
Article in English | WPRIM | ID: wpr-762146
ABSTRACT
Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to the most common subtype of chronic urticaria. The underlying pathophysiology for CSU involves mast cell and basophil degranulation with release of histamine, leukotrienes, prostaglandins and other inflammatory mediators. Although a variety of treatments exist, many patients do not tolerate or benefit from the existing therapies and even require more effective treatments. Omalizumab is currently the only licensed biologic for antihistamine-refractory CSU, and novel drugs are under development. This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Urticaria / Basophils / Biological Products / Histamine / Prostaglandins / Leukotrienes / Omalizumab / Angioedema / Mast Cells Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Urticaria / Basophils / Biological Products / Histamine / Prostaglandins / Leukotrienes / Omalizumab / Angioedema / Mast Cells Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2019 Type: Article