Sugammadex associated profound bradycardia and sustained hypotension in patient with the slow recovery of neuromuscular blockade: A case report
Anesthesia and Pain Medicine
;
: 299-304, 2019.
Article
in English
| WPRIM
| ID: wpr-762272
ABSTRACT
BACKGROUND:
New complications associated with sugammadex have been increased since its widespread use. We report a case of an 80-year-old male who experienced profound bradycardia and sustained hypotension after administration of sugammadex. CASE Following administration of 200 mg sugammadex after laparoscopic cholecystectomy, sudden bradycardia (29 beats/min) developed for 10 seconds and his train-of-four (TOF) ratio remained at 0.2 for 5 min. An additional 200 mg sugammadex was administered and profound bradycardia (21–30 beats/min) and hypotension (60/40 mmHg) developed. Atropine at 0.5 mg was administered, but the effect lasted only 30 s. Profound bradycardia occurred four more times at 30 s intervals, and ephedrine and phenylephrine were injected intermittently to increase the patient's heart rate and blood pressure. The TOF ratio became 0.9 about 10 min after administration of additional sugammadex.CONCLUSIONS:
Awareness must be heightened regarding the possibility of sugammadexinduced bradycardia and hypotension, and more attention should be paid to patients with slow recovery times following muscle relaxation, despite the use of sugammadex.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylephrine
/
Postoperative Complications
/
Atropine
/
Blood Pressure
/
Bradycardia
/
Cholecystectomy, Laparoscopic
/
Neuromuscular Blockade
/
Ephedrine
/
Heart Rate
/
Hypotension
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Anesthesia and Pain Medicine
Year:
2019
Type:
Article
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