Association of metformin and statin medications with surrogate measures of cardiovascular disease in youth with type 1 diabetes: the SEARCH for diabetes in youth study
Annals of Pediatric Endocrinology & Metabolism
;
: 187-194, 2019.
Article
in English
| WPRIM
| ID: wpr-762613
ABSTRACT
PURPOSE:
Youth with type 1 diabetes mellitus (T1DM) are at risk of cardiovascular disease (CVD). We evaluated if metformin or statin use was associated with surrogate measures of improved CVD.METHODS:
We included participants from the SEARCH observational study. Participants treated with insulin plus metformin (n=42) or insulin plus statin (n=39) were matched with 84 and 78 participants, respectively, treated with insulin alone. Measures of arterial stiffness obtained were pulse wave velocity (PWV), augmentation index (AI75), and heart rate variability as standard deviation of the normal-to-normal interval (SDNN) and root mean square differences of successive NN intervals (RMSSD).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cardiovascular Diseases
/
Prospective Studies
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Morinda
/
Diabetes Mellitus, Type 1
/
Vascular Stiffness
/
Pulse Wave Analysis
/
Observational Study
/
Heart Rate
/
Insulin
Type of study:
Observational study
Limits:
Adolescent
/
Humans
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2019
Type:
Article
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