Arterial stiffness in young women with Turner syndrome using cardio-ankle vascular index
Annals of Pediatric Endocrinology & Metabolism
;
: 158-163, 2019.
Article
in English
| WPRIM
| ID: wpr-762617
ABSTRACT
PURPOSE:
Patients with Turner syndrome (TS) have increased risk of morbidities and mortality related to cardiovascular complications. Cardio-ankle vascular index (CAVI) is a novel method of evaluating arterial stiffness independent of changes in blood pressure. We compared arterial stiffness using CAVI between TS patients and healthy control subjects.METHODS:
Nineteen young women with TS (mean, 26.8 years; range, 20.0–35.1 years) and 23 healthy women matched for age and body mass index (BMI) were recruited for CAVI measurements at Seoul National University Hospital between 2010 and 2013. Anthropometric parameters, fasting blood testing and measurements of CAVI were compared between the 2 groups.RESULTS:
TS patients were significantly shorter (mean 150.1 cm vs. 160.7 cm, P<0.001) and had lower body weight (mean 47.0 kg vs. 55.5 kg, P=0.014) than healthy controls, without difference in BMI. CAVI (6.5±0.6 vs. 6.1±0.6, P=0.039) was significantly higher in TS patients compared to healthy controls. Age was positively associated with CAVI (r=0.403, P=0.008) in univariate analysis. After adjusting for age, TS was associated with CAVI (P=0.006).CONCLUSION:
Young women with TS showed increased arterial stiffness measured by CAVI compared to healthy women after adjusting for age, suggesting inherent vasculopathy in TS patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Turner Syndrome
/
Blood Pressure
/
Body Weight
/
Body Mass Index
/
Mortality
/
Fasting
/
Cardiovascular Abnormalities
/
Vascular Stiffness
/
Seoul
/
Hematologic Tests
Type of study:
Prognostic study
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2019
Type:
Article
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