Your browser doesn't support javascript.
loading
Comparative study of indocyanine green combined with blue dye with methylene blue only and carbon nanoparticles only for sentinel lymph node biopsy in breast cancer
Article in English | WPRIM | ID: wpr-762684
Responsible library: WPRO
ABSTRACT

PURPOSE:

The combination of indocyanine green and methylene blue (ICG + MB) was reported to be an efficient tracer method in sentinel lymph node biopsy (SLNB). However, whether this method is superior to MB only or carbon nanoparticles (CN) is controversial. This study was to evaluate the efficacy of the three methods in SLNB for breast cancer, and to analyze its influencing factors.

METHODS:

One hundred eighty patients with early breast cancer were recruited and randomly divided into 3 groups. Each group comprising of 60 patients with SLNB using ICG + MB, MB, and CN, respectively. Then the 3 groups were compared in detection rate, mean number of SLNs, and the detection rates and number of metastatic sentinel lymph nodes (SLNs).

RESULTS:

The detection rate of SLNs was 100% (60 of 60) in ICG + MB group, 96.7% (58 of 60), and 98.3% (59 of 60) in MB and CN group, respectively, with no significant difference (P = 0.362). Totally, 204 SLNs (mean ± standard deviation [SD] [range], 3.4 ± 1.4 [2–8]) were detected in ICG + MB group, 102 (1.7 ± 0.7 [0–3]) and 145 (2.4 ± 0.7 [0–6]) in MB and CN group, indicating significant difference (P < 0.001). The detection rate of metastatic SLN was 23.3% (14 of 60) in ICG + MB group, which was higher than 18.3% (11 of 60) and 20% (11 of 60) in MB and CN group, respectively, but showed no statistical significance (P = 0.788).

CONCLUSION:

ICG + MB method was superior to MB only and CN only methods in the mean number of SLNs, thus predicting axillary lymph node metastasis more accurately. Therefore, in areas where the standard method is not available, ICG + MB may be more suitable as an alternative tracer for SLNB.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Breast / Breast Neoplasms / Humans / Carbon / Sentinel Lymph Node Biopsy / Nanoparticles / Indocyanine Green / Lymph Nodes / Methods / Methylene Blue Language: English Journal: Annals of Surgical Treatment and Research Year: 2019 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Breast / Breast Neoplasms / Humans / Carbon / Sentinel Lymph Node Biopsy / Nanoparticles / Indocyanine Green / Lymph Nodes / Methods / Methylene Blue Language: English Journal: Annals of Surgical Treatment and Research Year: 2019 Type: Article