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IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
Asia Pacific Allergy ; (4): e30-2019.
Article in English | WPRIM | ID: wpr-762879
ABSTRACT
Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Protons / Skin Tests / Incidence / Proton Pumps / Drug Hypersensitivity / Proton Pump Inhibitors / Gastrointestinal Diseases / Hypersensitivity / Anaphylaxis Type of study: Incidence study / Prognostic study Limits: Female / Humans Language: English Journal: Asia Pacific Allergy Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Protons / Skin Tests / Incidence / Proton Pumps / Drug Hypersensitivity / Proton Pump Inhibitors / Gastrointestinal Diseases / Hypersensitivity / Anaphylaxis Type of study: Incidence study / Prognostic study Limits: Female / Humans Language: English Journal: Asia Pacific Allergy Year: 2019 Type: Article