Quantitative Predictive Imaging Biomarkers of Lumbar Intervertebral Disc Degeneration
Asian Spine Journal
;
: 527-534, 2019.
Article
in English
| WPRIM
| ID: wpr-762977
ABSTRACT
STUDY DESIGN:
Observational comparative study.PURPOSE:
To compare fractional anisotropy (FA) maps with T2 values of the nucleus pulposus (NP) and annulus fibrosus (AF) of intervertebral discs in healthy volunteers and patients to develop a predictive disc health scale. OVERVIEW OF LITERATURE T2-weighted magnetic resonance imaging (MRI) is not sensitive to early morphological changes and provides no quantitative biomarker profile for early degeneration.METHODS:
We examined 59 healthy controls and 59 patients with back pain by MRI using T2 relaxometry and diffusion tensor imaging (DTI). Each group was divided into three age subgroups A (50 years, n=21). We obtained FA values for AF and NP and T2 values for NP for each intervertebral disc. Furthermore, we calculated the FA (AF/NP) ratios.RESULTS:
We categorized 590 intervertebral discs from 118 participants, 566 of which were analyzed with T2 relaxometry and DTI. The T2 values were as follows subgroup A, 55.8±4.4 ms; B, 48.5±6.9 ms; C, 45.8±8.7 ms (p120 ms, 90–100 ms, and 70 ms, respectively (p<0.001). Control subgroup A had higher T2 values and AF/NP ratios than subgroups B and C; the AF values were not significantly different. Control subgroup B had higher T2 values and AF/NP ratios than subgroup C but lower FA (NP).CONCLUSIONS:
FA maps of the AF/NP ratio and T2 values of NP are potential microstructure biomarkers of normal and degenerating discs and can help detect early degeneration using a predictive disc health score on a continuous scale.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Magnetic Resonance Imaging
/
Biomarkers
/
Anisotropy
/
Back Pain
/
Intervertebral Disc Degeneration
/
Diffusion Tensor Imaging
/
Healthy Volunteers
/
Intervertebral Disc
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Asian Spine Journal
Year:
2019
Type:
Article
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