Differential Gene Expression Common to Acquired and Intrinsic Resistance to BRAF Inhibitor Revealed by RNA-Seq Analysis

Jun-Ho AHN; Sung-Hee HWANG; Hyun-Soo CHO; Michael LEE

Jun-Ho AHN; Sung-Hee HWANG; Hyun-Soo CHO; Michael LEE.

Biomolecules & Therapeutics ; : 302-310, 2019.

Article in English | WPRIM | ID: wpr-763014

ABSTRACT

ABSTRACT

Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and

Subject(s)

Antigen Presentation; Biological Phenomena; Cell Adhesion; Cell Line; Cell Movement; Classification; Collagen; Drug Resistance; Extracellular Matrix; Gene Expression; Gene Ontology; Melanoma; Osteoblasts; Proto-Oncogene Proteins c-akt

BRAF inhibitor; Drug resistance; Melanoma; RNA-Seq analysis

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Biological Phenomena / Drug Resistance / Gene Expression / Cell Adhesion / Cell Line / Cell Movement / Collagen / Classification / Antigen Presentation Language: English Journal: Biomolecules & Therapeutics Year: 2019 Type: Article

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