4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
Biomolecules & Therapeutics
;
: 381-385, 2019.
Article
in English
| WPRIM
| ID: wpr-763025
ABSTRACT
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage RAW 264.7 cells, it significantly suppressed lipopolysaccharide (LPS)-induced generation of prostaglandin E₂ (PGE₂) and nitric oxide (NO) through transcriptional inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). GOMV also scavenged free radicals in vitro, increased NF-E2-related factor 2 (NRF2), and activated antioxidant response element (ARE), thereby resulting in the induction of phase II cytoprotective enzymes in human keratinocyte HaCaT cells. Finally, GOMV significantly protected HaCaT cells against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative intracellular damages. Together, our results illustrate that GOMV possesses anti-inflammatory and anti-oxidant activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
In Vitro Techniques
/
Histones
/
Keratinocytes
/
Cyclooxygenase 2
/
Nitric Oxide Synthase Type II
/
NF-E2-Related Factor 2
/
Epigenomics
/
Antioxidant Response Elements
/
Free Radicals
Limits:
Humans
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2019
Type:
Article
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