Determining the risk factors associated with the development of Clostridium difficile infection in patients with hematological diseases
Blood Research
;
: 120-124, 2019.
Article
in English
| WPRIM
| ID: wpr-763061
ABSTRACT
BACKGROUND:
Clostridium difficile infection (CDI) is a nosocomial condition prevalent in patients with hematological disorders. We aimed to identify the risk factors associated with the development of CDI and assess the mortality rate at 15 and 30 days among hematologic patients admitted to a tertiary care center.METHODS:
We conducted a retrospective case-control study from January 2010 to December 2015. Forty-two patients with hematologic malignancy and CDI, and 84 with hematologic disease and without history of CDI were included in the case and control groups, respectively.RESULTS:
Univariate analysis revealed that episodes of febrile eutropenia [odds ratio (OR), 5.5; 95% confidence interval (CI), 2.3–12.9; P1 hospitalization (OR, 5.6; 95% CI, 2.5–12.6; P1 hospitalization (OR, 4.3; 95% CI, 1.7–11.0; P=0.002) were independent risk factors. Three (7.1%) and 6 (14.2%) case patients died at 15 and 30 days, respectively.CONCLUSION:
The risk factors for developing CDI were exposure to therapeutic antibiotics and previous hospitalization. Hematological patients who developed CDI had higher early mortality rates, suggesting that new approaches for prevention and treatment are needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Multivariate Analysis
/
Retrospective Studies
/
Risk Factors
/
Mortality
/
Clostridioides difficile
/
Clostridium
/
Hematologic Neoplasms
/
Tertiary Care Centers
/
Hematologic Diseases
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Blood Research
Year:
2019
Type:
Article
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