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Body Cavity–Based Lymphoma in a Country with Low Human Immunodeficiency Virus Prevalence: A Series of 17 Cases from the Consortium for Improving Survival of Lymphoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1302-1312, 2019.
Article in English | WPRIM | ID: wpr-763229
ABSTRACT

PURPOSE:

Primary effusion lymphoma (PEL) is a type of body cavity–based lymphoma (BCBL). Most patients with PEL are severely immunocompromised and seropositive for human immunodeficiency virus (HIV). We investigated the distinctive clinicopathologic characteristics of BCBL in a country with low HIV burden. MATERIALS AND

METHODS:

We retrospectively collected data on the clinicopathologic characteristics, treatments, and outcomes of 17 consecutive patients with BCBL at nine institutions in Korea.

RESULTS:

Latency-associated nuclear antigen 1 (LANA1) immunostaining indicated that six patients had PEL, six patients had human herpesvirus 8 (HHV8)-unrelated BCBL, and five patients had HHV8-unknown BCBL. The patients with PEL exhibited no evidence of immunodeficiency except for one who was HIV positive. One (20%) and four (80%) patients with PEL and six (100%) and zero (0%) patients with HHV8-unrelated BCBL were positive for CD20 and CD30 expression, respectively. The two patients with PEL (one HIV-positive and one HIV-negative patient) with the lowest proliferation activity as assessed by the Ki-67 labeling index survived for > 1 and > 4 years without chemotherapy, respectively, in contrast to the PEL cases in the literature, which mostly showed a high proliferation index and poor survival.

CONCLUSION:

PEL mostly occurred in ostensibly immunocompetent individuals and had a favorable outcome in Korea. A watchful waiting approach may be applicable for managing HIV-seronegative patients with PEL with a low Ki-67 labeling index. A possible trend was detected among LANA1, CD20, and CD30 expression in BCBL.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prevalence / Retrospective Studies / HIV / Herpesvirus 8, Human / Drug Therapy / Lymphoma, Primary Effusion / Watchful Waiting / Korea / Lymphoma Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prevalence / Retrospective Studies / HIV / Herpesvirus 8, Human / Drug Therapy / Lymphoma, Primary Effusion / Watchful Waiting / Korea / Lymphoma Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2019 Type: Article