Cognitive Therapy Combined with Drug Treatment in Patients with Alzheimer's Disease: A Neuropsychological and Positron Emission Tomography Investigation, a Pilot Study
Dementia and Neurocognitive Disorders
;
: 76-82, 2015.
Article
in English
| WPRIM
| ID: wpr-76325
ABSTRACT
BACKGROUND:
Cognitive therapy may have therapeutic benefit in patients with early Alzheimer's disease (AD). CASE REPORT This was a 12-week, single-blind pilot study of 4 patients with AD. The cognitive therapy included exercises for orientation to time and place; memory training, including face-name association, object recall training, and spaced retrieval; visuo-motor organization using software; similarity and ruled based categorization; and behavior modification and sequencing (e.g., making change, paying bills). The regional cerebral metabolic abnormalities and the effects of treatment on cortical metabolic responses were evaluated using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET). After 12 weeks, the participants showed slight improvement in some neuropsychological measures, and three of them showed increased regional cortical metabolism on brain PET studies.CONCLUSIONS:
Cognitive therapy may stabilize or improve cognitive and functional performance of patients with early AD and increase regional cortical metabolism of the patients' brain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Behavior Therapy
/
Brain
/
Exercise
/
Cognitive Behavioral Therapy
/
Pilot Projects
/
Positron-Emission Tomography
/
Alzheimer Disease
/
Learning
/
Metabolism
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Dementia and Neurocognitive Disorders
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS