Antibiotic Sensitivity Patterns in Children with Urinary Tract Infection: Retrospective Study Over 8 Years in a Single Center
Childhood Kidney Diseases
;
: 22-28, 2019.
Article
in English
| WPRIM
| ID: wpr-763267
ABSTRACT
PURPOSE:
We studied the pathogens and trends in antibiotic sensitivity pattern in children with urinary tract infection (UTI) over 8 years in order to evaluate adequate treatment.METHODS:
We performed a retrospective review of medical records of children with UTI from January 2009 to December 2016 in Daegu Fatima Hospital. Uropathogens and antibiotic sensitivity patterns were selected. Only 1 bacterial species with a colony count of ≥105 CFU/mL was considered a positive result. We compared 2 periods group (A 2009~2012, B 2013~2016) to investigate trends of antibiotic sensitivity pattern.RESULTS:
During the 8 year period, 589 cases are identified (E. coli was cultured in 509 cases, 86.4%). Among all patients, this study investigated the antibiotic sensitivity of E. coli . Antimicrobial susceptibility to ampicillin was steadily low for both periods (A 32.6%, B 40.1%, P=0.125), and to amikacin was consistently high for both periods (A 99.4%, B 99.3%, P=1.000). Antibiotic sensitivity to third-generation cephalosporin decreased from period A to B (A 91.7%, B 75.5%, P=0.000). Antibiotic sensitivity to quinolone significantly decreased from A to B (A 88.4%, B 78.2%, P=0.003). The prevalence of extended-spectrum β-lactamase-producing E. coli increased from period A to B (A 6.1%, B 17.1%, P=0.000).CONCLUSION:
This study showed that conventional antibiotic therapy for the treatment of pediatric UTI needs to be reevaluated. A careful choice of antibiotic is required due to the change in antibiotic sensitivity and the emergence of antibiotic-resistant bacteria.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
Urinary Tract
/
Urinary Tract Infections
/
Amikacin
/
Medical Records
/
Prevalence
/
Retrospective Studies
/
Ampicillin
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Childhood Kidney Diseases
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS