Neutrophils as a Protagonist and Target in Chronic Rhinosinusitis
Clinical and Experimental Otorhinolaryngology
;
: 337-347, 2019.
Article
in English
| WPRIM
| ID: wpr-763338
ABSTRACT
Neutrophils have traditionally been acknowledged as the first immune cells that are recruited to inflamed tissues during acute inflammation. By contrast, their importance in the context of chronic inflammation has been studied in less depth. Neutrophils can be recruited and are largely present in the nasal mucosa of patients with chronic rhinosinusitis (CRS) both in Asians and in Caucasians. Increased infiltration of neutrophils in patients with CRS has been linked to poor corticosteroid response and disease prognosis. Meanwhile, tissue neutrophils may possess specific phenotypic features distinguishing them from resting blood counterparts and are endowed with particular functions, such as cytokines and chemokines production, thus may contribute to the pathogenesis of CRS. This review aims to summarize our current understanding of the pathophysiologic mechanisms of CRS, with a focus on the roles of neutrophils. We discuss recruitment, function, and regulation of neutrophils in CRS and outline the potential therapeutic strategies targeting neutrophils.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Nasal Polyps
/
Cytokines
/
Chemokines
/
Asian People
/
Inflammation
/
Nasal Mucosa
/
Neutrophils
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2019
Type:
Article
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