Investigation of the association of idiopathic male infertility with polymorphisms in the methionine synthase (MTR) gene / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 107-111, 2019.
Article
in English
| WPRIM
| ID: wpr-763364
ABSTRACT
OBJECTIVE:
Spermatogenesis is a complex process that is regulated by a number of genes, some of which are involved in folate-dependent 1-carbon metabolism. Methionine synthase (encoded by MTR) is a key enzyme participating in this pathway. This study aimed to investigate the relationship of the MTR 2756A > G polymorphism with idiopathic male fertility in the Iranian population.METHODS:
The participants of this study included 100 men with idiopathic infertility and 100 healthy men as the control group. Genotyping of MTR 2756A > G was performed using the polymerase chain reaction and restriction fragment length polymorphism technique. The obtained data were analyzed using SPSS ver. 20.0 with a level of confidence of p G single-nucleotide polymorphism is not a predisposing factor for idiopathic infertility in men.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatogenesis
/
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
/
Polymorphism, Restriction Fragment Length
/
Polymerase Chain Reaction
/
Causality
/
Alleles
/
Fertility
/
Genotype
/
Infertility
/
Infertility, Male
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2019
Type:
Article
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