Understanding the molecular mechanisms of bisphenol A action in spermatozoa / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 99-106, 2019.
Article
in English
| WPRIM
| ID: wpr-763365
ABSTRACT
Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatozoa
/
Oxidative Stress
/
Consensus
/
Endocrine System
/
Endocrine Disruptors
Type of study:
Practice guideline
Limits:
Humans
/
Male
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2019
Type:
Article
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