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Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue
Clinical Endoscopy ; : 464-471, 2019.
Article in English | WPRIM | ID: wpr-763473
ABSTRACT
BACKGROUND/

AIMS:

Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues.

METHODS:

Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC.

RESULTS:

Cancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection.

CONCLUSIONS:

The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Vimentin / Biopsy / Immunohistochemistry / Transforming Growth Factors / Cadherins / Down-Regulation / Up-Regulation / Prospective Studies / Follow-Up Studies Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Clinical Endoscopy Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Vimentin / Biopsy / Immunohistochemistry / Transforming Growth Factors / Cadherins / Down-Regulation / Up-Regulation / Prospective Studies / Follow-Up Studies Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Clinical Endoscopy Year: 2019 Type: Article