Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 115-118, 2019.
Article
in English
| WPRIM
| ID: wpr-763511
ABSTRACT
A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir resulted in successful resolution of CMV retinitis. Another 13 year-old boy with ALL on maintenance chemotherapy presented with prolonged fever with no response to antibiotics administration. CMV and real-time PCR revealed positive result and a titer of 2,618,700 copies/mL, respectively. Ganciclovir was used for more than the approved duration of treatment, but viral titer frequently recurred with elevated liver enzymes and fever. In these 2 cases of CMV infection, a high index of suspicion and prompt management is important in children receiving ALL chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinitis
/
Ganciclovir
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Fever
/
Maintenance Chemotherapy
/
Real-Time Polymerase Chain Reaction
/
Liver
Limits:
Child
/
Humans
/
Male
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2019
Type:
Article
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