Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
Clinical Psychopharmacology and Neuroscience
;
: 170-182, 2019.
Article
in English
| WPRIM
| ID: wpr-763540
ABSTRACT
Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discusses how corollary discharge model is an essential neural integration mechanism central to the motor functioning of animal kingdom. In this article, research conducted in the field of corollary discharge has been reviewed to understand the neuroanatomical and neurophysiological basis of corollary discharge and gain insight into the biochemical basis of its dysfunction. This review article also explores the role of corollary discharge and its dysfunction in the presentation of symptoms of schizophrenia, discussing the findings from corollary discharge studies on schizophrenia population. Lastly, the link between schizophrenia psychopathology and corollary discharge dysfunction has been highlighted, and an attempt has been made to establish a case for correction of corollary discharge deficit in schizophrenia through neuromodulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychopathology
/
Schizophrenia
/
Discrimination, Psychological
/
Transcranial Direct Current Stimulation
/
Hallucinations
/
Motor Activity
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS