Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats
Clinical Psychopharmacology and Neuroscience
;
: 400-408, 2019.
Article
| WPRIM
| ID: wpr-763553
ABSTRACT
OBJECTIVE:
This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats.METHODS:
Adolescent male Sprague-Dawley rats were injected intraperitoneally with aripiprazole, risperidone, or vehicle control for 3 weeks (postnatal day 36–56). After a 2-week washout period, locomotion, anxiety, and spatial working memory were evaluated in adulthood (postnatal day 71–84), using an open field test, elevated plus maze, and Y-maze, respectively. In addition, we assessed D2R levels in the dorsolateral and medial prefrontal cortex (PFC), dorsal and ventral striatum, and hippocampus using western blot analysis.RESULTS:
Spontaneous alternation performance (SAP) in the Y-maze, a measure of spatial working memory, differed significantly among the 3 groups (F = 3.89, p = 0.033). A post-hoc test confirmed that SAP in the aripiprazole group was significantly higher than that in the risperidone group (post-hoc test p = 0.013). D2R levels in the medial PFC (F = 8.72, p = 0.001) and hippocampus (F = 13.54, p < 0.001) were different among the 3 groups. D2R levels in the medial PFC and hippocampus were significantly lower in the aripiprazole-treated rats than that in the risperidone-treated rats (post-hoc test p = 0.025 and p < 0.001, respectively) and controls (post-hoc test p < 0.001, all).CONCLUSION:
This study showed that aripiprazole treatment in adolescence could influence cognitive function and dopaminergic neurotransmission into early adulthood.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Dopamine
/
Blotting, Western
/
Receptors, Dopamine D2
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Rats, Sprague-Dawley
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Prefrontal Cortex
/
Cognition
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Synaptic Transmission
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Risperidone
/
Models, Animal
Limits:
Animals
/
Humans
/
Male
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2019
Type:
Article
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