Relating Prognosis in Chromophobe Renal Cell Carcinoma to the Chromophobe Tumor Grading System
Korean Journal of Urology
;
: 239-244, 2014.
Article
in English
| WPRIM
| ID: wpr-76361
ABSTRACT
PURPOSE:
The chromophobe subtype of renal cell carcinoma (chRCC) has generally been associated with a better prognosis than the clear cell type; however, debate continues as to absolute prognosis as well as the significance of certain prognostic variables. We investigated the significance of pathologic stage and a recently proposed chromophobe tumor grading (CTG) scheme in predicting chRCC outcomes. MATERIALS ANDMETHODS:
All available chRCCs were identified from our surgical pathology archives from 1987-2010. Original slides were reviewed to verify diagnoses and stage, and each case was graded following a novel chromophobe tumor grade system criteria. Disease status was obtained from a clinical outcome database, and cancer specific deaths and recurrences were recorded.RESULTS:
Eighty-one cases of chRCC were identified, and 73 had adequate follow-up information available. There were only 3 instances of cancer related recurrence or mortality, which included 1 disease specific mortality and 2 disease recurrences. Pathologic stage and CTG 3 were found to be significantly associated with the recurrences or death from chRCC, but there was no association with CTG 1 and CTG 2.CONCLUSIONS:
chRCC is associated with a very low rate of cancer specific events (4.1%) even at a tertiary referral center. In our study, pathologic stage and CTG 3, but not CTG 1 or 2, were significantly associated with the development of these events.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology, Surgical
/
Prognosis
/
Recurrence
/
Carcinoma, Renal Cell
/
Follow-Up Studies
/
Mortality
/
Diagnosis
/
Neoplasm Grading
/
Tertiary Care Centers
/
Nephrectomy
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Korean Journal of Urology
Year:
2014
Type:
Article
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