Your browser doesn't support javascript.
loading
Asian Subpopulations May Exhibit Greater Cardiovascular Benefit from Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A Meta-Analysis of Cardiovascular Outcome Trials
Diabetes & Metabolism Journal ; : 410-421, 2019.
Article in English | WPRIM | ID: wpr-763668
ABSTRACT

BACKGROUND:

Based on reported results of three large cardiovascular outcome trials (CVOTs) of glucagon-like peptide 1 receptor agonists (GLP-1 RAs), we aimed to investigate the overall effect of GLP-1 RAs on major adverse cardiovascular events (MACEs) and to identify subpopulations exhibiting the greatest cardiovascular (CV) benefit.

METHODS:

Three CVOTs reporting effects of long-acting GLP-1 RAs were included LEADER (liraglutide), SUSTAIN-6 (semaglutide), and EXSCEL (exenatide once weekly). In all studies, the primary endpoint was three-point MACE, comprising CV death, non-fatal myocardial infarction, and non-fatal stroke. Overall effect estimates were calculated as hazard ratios and 95% confidence intervals (CIs) using the random-effects model; subgroup analyses reported in the original studies were similarly analyzed.

RESULTS:

Overall, statistically significant risk reductions in MACE and CV death were observed. Subgroup analysis indicated a significant racial difference with respect to CV benefit (P for interaction <0.001), and more substantial risk reductions were observed in subjects of African origin (relative risk [RR], 0.78; 95% CI, 0.60 to 0.99) and in Asians (RR, 0.35; 95% CI, 0.09 to 1.32). However, post hoc analysis (Bonferroni method) revealed that only Asians exhibited a significantly greater CV benefit from treatment, compared with white subjects (P<0.0001).

CONCLUSION:

Long-acting GLP-1 RAs reduced risks of MACE and CV deaths in high-risk patients with type 2 diabetes mellitus. Our findings of a particularly effective reduction in CV events with GLP-1 RA in Asian populations merits further exploration and dedicated trials in specific populations.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular Diseases / Stroke / Asian People / Diabetes Mellitus, Type 2 / Glucagon-Like Peptide 1 / Incretins / Myocardial Infarction Type of study: Etiology study / Prognostic study / Systematic reviews Limits: Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular Diseases / Stroke / Asian People / Diabetes Mellitus, Type 2 / Glucagon-Like Peptide 1 / Incretins / Myocardial Infarction Type of study: Etiology study / Prognostic study / Systematic reviews Limits: Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2019 Type: Article