Associations of Metabolic Syndrome with Total Testosterone and Homocysteine Levels in Male Korean Workers
Endocrinology and Metabolism
;
: 158-168, 2019.
Article
in English
| WPRIM
| ID: wpr-763698
ABSTRACT
BACKGROUND:
Low testosterone is associated with metabolic syndrome (MetS), and homocysteine (Hcy) is elevated in individuals with MetS. We investigated the relationships of total testosterone (TT) and serum Hcy levels with MetS in male Korean workers.METHODS:
We conducted a cross-sectional study including 8,606 male workers, aged 20 to 58 years, who underwent a physical examination in 2015. MetS was diagnosed based on the criteria of the 2009 harmonized definition, while the Korean standard for waist circumference (WC) was used. Participants' biochemical parameters, including TT and serum Hcy, were measured, and participants were divided into quartiles. Multiple logistic regression models were used to estimate the association of MetS and its individual components depending on TT and serum Hcy quartiles.RESULTS:
The prevalence of MetS in the study population was 16%. TT was lower in participants with MetS than in those without MetS (P<0.001). By contrast, Hcy level was similar between groups (P=0.694). In multiple logistic regression analysis, the odds ratio for the lowest TT quartile was 1.29 (95% confidence interval, 1.06 to 1.57) after adjusting for potential confounders. Participants with lower TT were more likely to have high WC, hypertriglyceridemia, and low high density lipoprotein levels. Serum Hcy levels were not significantly associated with MetS. Of the five components of MetS, only WC was significantly associated with serum Hcy.CONCLUSION:
In male Korean workers, TT may be an independent predictor of MetS, and serum Hcy levels could be a marker of abdominal obesity. However, future prospective studies are needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Examination
/
Testosterone
/
Hypertriglyceridemia
/
Logistic Models
/
Odds Ratio
/
Prevalence
/
Cross-Sectional Studies
/
Prospective Studies
/
Waist Circumference
/
Obesity, Abdominal
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS