Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala
Experimental Neurobiology
;
: 320-328, 2019.
Article
in English
| WPRIM
| ID: wpr-763772
ABSTRACT
The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors formation and extinction of fear memory and appetitive instrumental learning. However, the cholinergic mechanism at the circuit level has not been defined yet. We demonstrated that cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons exhibits a retrograde form of short-term synaptic inhibition, depolarization-induced suppression of inhibition (DSI). Activation of nicotinic receptors was sufficient to evoke action potentials in cholecystokinin (CCK)-positive inhibitory neurons, which strongly inhibit pyramidal neurons through their perisomatic synapses. Our cell type-specific monosynaptic retrograde tracing also revealed that CCK neurons are innervated by basal forebrain cholinergic neurons. Therefore, our data indicated that CCK inhibitory neurons mediate the cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Synapses
/
Action Potentials
/
Cholecystokinin
/
Acetylcholine
/
Iontophoresis
/
Receptors, Nicotinic
/
Pyramidal Cells
/
Conditioning, Operant
/
Cholinergic Neurons
/
Basolateral Nuclear Complex
Language:
English
Journal:
Experimental Neurobiology
Year:
2019
Type:
Article
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