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Axon Guidance Molecules Guiding Neuroinflammation
Experimental Neurobiology ; : 311-319, 2019.
Article in English | WPRIM | ID: wpr-763773
ABSTRACT
Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are also important in the postnatal period, such as in the regulation of immune and inflammatory responses. In particular, AGMs play pivotal roles in inflammation of the nervous system, by either stimulating or inhibiting inflammatory responses, depending on specific ligand-receptor combinations. Understanding such regulatory functions of AGMs in neuroinflammation may allow finding new molecular targets to treat neurodegenerative diseases, in which neuroinflammation underlies aetiology and progression.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Axons / Neuroglia / Neurodegenerative Diseases / Ephrins / Semaphorins / Inflammation / Nervous System Type of study: Practice guideline Language: English Journal: Experimental Neurobiology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Axons / Neuroglia / Neurodegenerative Diseases / Ephrins / Semaphorins / Inflammation / Nervous System Type of study: Practice guideline Language: English Journal: Experimental Neurobiology Year: 2019 Type: Article