Identification of ERBB Pathway-Activated Cells in Triple-Negative Breast Cancer
Genomics & Informatics
;
: e3-2019.
Article
in English
| WPRIM
| ID: wpr-763800
ABSTRACT
Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast cancer is a significant challenge for effective treatment. Using single-cell RNA sequencing (RNA-seq) data from a public resource, an ERBB pathway activated triple-negative cell population was identified. The differential expression of three subtyping marker genes (ERBB2, ESR1, and PGR) was not changed in the bulk RNA-seq data, but the single-cell transcriptomes showed intratumor heterogeneity. This result shows that ERBB signaling is activated using an indirect route and that the molecular subtype is changed on a single-cell level. Our data propose a different view on breast cancer subtypes, clarifying much confusion in this field and contributing to precision medicine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Population Characteristics
/
Breast Neoplasms
/
Sequence Analysis, RNA
/
Precision Medicine
/
Transcriptome
/
Triple Negative Breast Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Genomics & Informatics
Year:
2019
Type:
Article
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