Identification of neoantigens derived from alternative splicing and RNA modification
Genomics & Informatics
;
: e23-2019.
Article
in English
| WPRIM
| ID: wpr-763824
ABSTRACT
The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
RNA
/
Mass Screening
/
Sequence Analysis, RNA
/
RNA Editing
/
Alternative Splicing
/
Carcinogenesis
/
Immune System
/
Immunotherapy
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
English
Journal:
Genomics & Informatics
Year:
2019
Type:
Article
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