Your browser doesn't support javascript.
loading
Increased Risk of Herpes Zoster in Young and Metabolically Healthy Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
Gut and Liver ; : 333-341, 2019.
Article in English | WPRIM | ID: wpr-763845
ABSTRACT
BACKGROUND/

AIMS:

The risk of herpes zoster (HZ) among patients with inflammatory bowel disease (IBD) remains unclear in terms of age and metabolic comorbidities, including diabetes mellitus, hypertension, or dyslipidemia. We conducted a nationwide population-based study to investigate the risk of HZ in patients with IBD.

METHODS:

From 2010 to 2013, a retrospective study was performed using claims data in Korea. We compared the incidence of HZ between 30,100 IBD patients (10,517 Crohn’s disease [CD] and 19,583 ulcerative colitis [UC] patients) and 150,500 non-IBD controls matched by age and sex.

RESULTS:

During a mean follow-up of 5.0 years, incidence rates of HZ (per 1,000 person-years) were 13.60, 14.99, and 9.19 in the CD, UC, and control groups, respectively. The risk of HZ was significantly higher in patients with CD (adjusted hazard ratio [HR], 2.13; p<0.001) and UC (adjusted HR, 1.40; p<0.001) than in the controls. The impact of CD on developing HZ was significantly more prominent in younger patients (adjusted HR, 2.61 for age <15, whereas 1.39 for age ≥60; interaction p=0.001) and in patients without metabolic comorbidities (adjusted HR, 2.24, whereas 1.59 in those with metabolic comorbidities; interaction p=0.015). Moreover, the impact of UC on developing HZ significantly increased in younger patients (adjusted HR, 2.51 in age <15, whereas 1.22 in age ≥60; interaction p=0.014) and patients without metabolic comorbidities (adjusted HR, 1.49 whereas 1.16 in those with metabolic comorbidities; interaction p<0.001).

CONCLUSIONS:

IBD was associated with an increased risk of HZ, especially in younger patients without metabolic comorbidities.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Comorbidity / Incidence / Retrospective Studies / Follow-Up Studies / Diabetes Mellitus / Dyslipidemias / Herpes Zoster / Hypertension Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Gut and Liver Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Comorbidity / Incidence / Retrospective Studies / Follow-Up Studies / Diabetes Mellitus / Dyslipidemias / Herpes Zoster / Hypertension Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Gut and Liver Year: 2019 Type: Article