Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
International Journal of Oral Biology
;
: 20-26, 2019.
Article
in Korean
| WPRIM
| ID: wpr-764032
ABSTRACT
Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Diseases
/
Transducers
/
RNA, Messenger
/
Cardiovascular Diseases
/
Cell Movement
/
Porphyromonas
/
Porphyromonas gingivalis
/
Matrix Metalloproteinase 9
/
Atherosclerosis
/
STAT3 Transcription Factor
Limits:
Animals
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2019
Type:
Article
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