Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats
International Journal of Oral Biology
; : 55-61, 2019.
Article
in En
| WPRIM
| ID: wpr-764037
Responsible library:
WPRO
ABSTRACT
The purpose of this study was to evaluate the effect of mangosteen extract complex (MEC; Garcinia mangostana L. and propolis extracts) on the inhibition of inflammation and prevention of alveolar bone loss using a ligature-induced periodontitis model. Rat molars were ligatured with silk, and 1 µg/mL of lipopolysaccharide of Porphyromonas gingivalis was injected into the buccal and palatal gingivae of the teeth with or without treatment with the MEC. Changes in the expression levels of prostaglandin E₂ (PGE₂), interleukin-8 (IL-8), inducible nitric oxide synthase (iNOS), matrix metalloproteinase-8 (MMP-8), cyclooxygenase (COX)-1, and COX-2 in gingival tissues were evaluated using enzyme-linked immunosorbent assays. Alveolar bone loss around the ligated molars was examined using micro-computed tomography. The expression levels of PGE₂, IL-8, iNOS, MMP-8, COX-1, and COX-2 in gingival tissues were significantly reduced in the group treated with a mixture of 16 µg of mangosteen extract powder and 544 µg of propolis extract powder (ligation [Lig] + lipopolysaccharide extracted from P. gingivalis KCOM 2804 [L] + MEC 1:34). Additionally, alveolar bone loss was significantly reduced in the Lig + L + MEC 1:34 group compared with that in other groups. These results indicate that the MEC could be useful in preventing and treating periodontitis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Periodontitis
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Propolis
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Tooth
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Enzyme-Linked Immunosorbent Assay
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Alveolar Bone Loss
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Interleukin-8
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Prostaglandin-Endoperoxide Synthases
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Porphyromonas gingivalis
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Matrix Metalloproteinase 8
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Garcinia
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
International Journal of Oral Biology
Year:
2019
Type:
Article