Preparation and characterization of rutile phase TiO₂ nanoparticles and their cytocompatibility with oral cancer cells
International Journal of Oral Biology
;
: 108-114, 2019.
Article
in English
| WPRIM
| ID: wpr-764043
ABSTRACT
In the present study, rutile phase titanium dioxide nanoparticles (R-TiO₂ NPs) were prepared by hydrolysis of titanium tetrachloride in an aqueous solution followed by calcination at 900℃. The composition of R-TiO₂ NPs was determined by the analysis of X-ray diffraction data, and the characteristic features of R-TiO₂ NPs such as the surface functional group, particle size, shape, surface topography, and morphological behavior were analyzed by Fourier-transform infrared spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy, transmission electron microscopy, dynamic light scattering, and zeta potential measurements. The average size of the prepared R-TiO₂ NPs was 76 nm, the surface area was 19 m²/g, zeta potential was −20.8 mV, and average hydrodynamic diameter in dimethyl sulfoxide (DMSO)–H₂O solution was 550 nm. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and morphological observations revealed that R-TiO₂ NPs were cytocompatible with oral cancer cells, with no inhibition of cell growth and proliferation. This suggests the efficacy of R-TiO₂ NPs for the aesthetic white pigmentation of teeth.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Spectrometry, X-Ray Emission
/
Spectrum Analysis
/
Titanium
/
Tooth
/
X-Ray Diffraction
/
Pigmentation
/
Mouth Neoplasms
/
Microscopy, Electron, Scanning
/
Dimethyl Sulfoxide
Language:
English
Journal:
International Journal of Oral Biology
Year:
2019
Type:
Article
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