Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neurons
International Journal of Stem Cells
;
: 340-346, 2019.
Article
in English
| WPRIM
| ID: wpr-764070
ABSTRACT
The concept of cellular reprogramming was developed to generate induced neural precursor cells (iNPCs)/dopaminergic (iDA) neurons using diverse approaches. Here, we investigated the effects of various nanoscale scaffolds (fiber, dot, and line) on iNPC/iDA differentiation by direct reprogramming. The generation and maturation of iDA neurons (microtubule-associated protein 2-positive and tyrosine hydroxylase-positive) and iNPCs (NESTIN-positive and SOX2-positive) increased on fiber and dot scaffolds as compared to that of the flat (control) scaffold. This study demonstrates that nanotopographical environments are suitable for direct differentiation methods and may improve the differentiation efficiency.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tyrosine
/
Cellular Reprogramming
/
Nanofibers
/
Neurons
Language:
English
Journal:
International Journal of Stem Cells
Year:
2019
Type:
Article
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