Your browser doesn't support javascript.
loading
Mesenchymal Stem Cells from the Wharton's Jelly of the Human Umbilical Cord: Biological Properties and Therapeutic Potential
Article in En | WPRIM | ID: wpr-764080
Responsible library: WPRO
ABSTRACT
Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs exhibit several features of embryonic stem cells, both in the phenotypic and genetic aspects, with only a few differences, such as a shorter doubling time and a more extensive ex vivo expansion capacity. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses. This review focuses on the role of WJ-MSCs in the management of graft-versus-host disease (GvHD), a life-threatening complication of the allogenic transplantation of hematopoietic stem cells. Different studies documented the beneficial effect of the infusion of WJ-MSCs, even when not fully HLA identical, in patients with severe GvHD, refractory to standard treatment. Finally, we summarized current ongoing clinical trials with WJ-MSCs and their potential in regenerative medicine.
Subject(s)
Key words
Full text: 1 Index: WPRIM Main subject: Stem Cells / Umbilical Cord / Hematopoietic Stem Cells / Regenerative Medicine / Ethics / Embryonic Stem Cells / Immunomodulation / Wharton Jelly / Mesenchymal Stem Cells / Graft vs Host Disease Limits: Humans Language: En Journal: International Journal of Stem Cells Year: 2019 Type: Article
Full text: 1 Index: WPRIM Main subject: Stem Cells / Umbilical Cord / Hematopoietic Stem Cells / Regenerative Medicine / Ethics / Embryonic Stem Cells / Immunomodulation / Wharton Jelly / Mesenchymal Stem Cells / Graft vs Host Disease Limits: Humans Language: En Journal: International Journal of Stem Cells Year: 2019 Type: Article