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Molecular Testing of Thyroid Indeterminate Nodules for Clinical Management Decision
International Journal of Thyroidology ; : 9-14, 2019.
Article in Korean | WPRIM | ID: wpr-764093
ABSTRACT
Thyroid nodules are the most common endocrine tumor. Ultrasonography and fine-needle aspiration (FNA) are currently accurate diagnostic tools for evaluating thyroid nodules. However, 10–30% of FNA specimens are cytologically indeterminate. Making an accurate diagnosis between benign and malignant nodules is important so that patients with malignant nodule receive proper treatment and patients with benign nodule can avoid unnecessary treatment. Several genetic changes such as point mutations of the BRAF or RAS and rearrangements of the RET/PTC1, RET/PTC3, PAX8/PPARY are used to adjust to indeterminate FNA. Such a mutational analysis has an excellent positive predictive value (PPV), but there is a weakness in the low negative predictive value (NPV). Gene-expression classifier (GEC) has been found helpful in identify nodules that are benign rather than malignant. GEC has an excellent NPV, but there is a weakness of low PPV. Multiplatform mutational and miRNA test (MPT) and next-generation sequencing assay (NGS) are being studied to compensate for these weaknesses. Molecular tests appear to be a good solution for improving the accuracy of indeterminate FNA cytology specimens and support the clinical management decisions in patients with indeterminate cytologic nodules, but further prospective multicenter trials are required for validation of reported findings and need evaluation of cost-effectiveness. This paper will review recently available molecular diagnostic tools of thyroid nodule.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Thyroid Gland / Thyroid Neoplasms / Prospective Studies / Multicenter Studies as Topic / Ultrasonography / Thyroid Nodule / Point Mutation / MicroRNAs / Biopsy, Fine-Needle / Diagnosis Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Korean Journal: International Journal of Thyroidology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Thyroid Gland / Thyroid Neoplasms / Prospective Studies / Multicenter Studies as Topic / Ultrasonography / Thyroid Nodule / Point Mutation / MicroRNAs / Biopsy, Fine-Needle / Diagnosis Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Korean Journal: International Journal of Thyroidology Year: 2019 Type: Article