Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer
Intestinal Research
;
: 404-412, 2019.
Article
in English
| WPRIM
| ID: wpr-764150
ABSTRACT
BACKGROUND/AIMS:
To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas.METHODS:
Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients.RESULTS:
The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm², respectively (P0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018)CONCLUSIONS:
VAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Glucose
/
Insulin Resistance
/
Colorectal Neoplasms
/
Tomography, X-Ray Computed
/
Adenoma
/
Adipose Tissue
/
Risk Factors
/
Colonoscopy
/
Fasting
/
Diagnosis
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Intestinal Research
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS