Human Epidermal Growth Factor Receptor 2-positive Mucinous Carcinoma with Signet Ring Cell Differentiation, Which Showed Complete Response after Neoadjuvant Chemotherapy / 한국유방암학회지
Journal of Breast Cancer
;
: 336-340, 2019.
Article
in English
| WPRIM
| ID: wpr-764258
ABSTRACT
Mucinous carcinoma (MC) is a rare subtype of breast cancer, which is composed of tumor cells floating in the abundant extracellular mucin. This form of cancer is usually estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative. Here, we present a case of HER2-positive MC with an unusual signet ring cell differentiation. It is very rare that a breast tumor consists entirely of signet ring cells. The tumor showed pathologic complete response (pCR) after neoadjuvant chemotherapy with trastuzumab and pertuzumab. pCR of HER2-positive MC has rarely been described in literature. It is important to consider the biological heterogeneity of MCs for effective management.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Population Characteristics
/
Breast Neoplasms
/
Cell Differentiation
/
Polymerase Chain Reaction
/
Carcinoma, Signet Ring Cell
/
Adenocarcinoma, Mucinous
/
Receptor, ErbB-2
/
Neoadjuvant Therapy
/
Drug Therapy
/
Epidermal Growth Factor
Limits:
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS