Cell Division Cycle Associated 8 Is a Key Regulator of Tamoxifen Resistance in Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
; : 237-247, 2019.
Article
in En
| WPRIM
| ID: wpr-764266
Responsible library:
WPRO
ABSTRACT
PURPOSE: Breast cancer (BC) is one of the most common malignancies globally, and millions of women worldwide are diagnosed with BC every year. Up to 70% of BC patients are estrogen receptor (ER)-positive. Numerous studies have shown that tamoxifen has a significant therapeutic effect on both primary and metastatic ER-positive BC patients. Although tamoxifen is currently one of the most successful therapeutic agents for BC, a significant proportion of patients will eventually become resistant to tamoxifen, leading to tumor recurrence and metastasis. Knowledge about the development of tamoxifen resistance in BC patients is still limited. METHODS: We applied a loss-and-gain method to study the biological functional role of cell division cycle associated 8 (CDCA8) in tamoxifen resistance in BC cells. RESULTS: We found that CDCA8 was significantly elevated in tamoxifen-resistant BC cells. Knockdown of CDCA8 expression significantly inhibited the proliferation of tamoxifen-resistant BC cells and reduced their resistance to tamoxifen. In contrast, overexpression of CDCA8 promoted the growth of tamoxifen-sensitive BC cells and induced their resistance to tamoxifen. CONCLUSION: In this study, we reported that CDCA8 is a key regulator of tamoxifen resistance in BC, suggesting that CDCA8 may serve as a potential therapeutic target for BC treatment.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Recurrence
/
Tamoxifen
/
Breast
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Breast Neoplasms
/
Cell Cycle
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Cell Division
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Apoptosis
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Estrogens
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Methods
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Neoplasm Metastasis
Limits:
Female
/
Humans
Language:
En
Journal:
Journal of Breast Cancer
Year:
2019
Type:
Article