The Roles of miRNAs in Medulloblastoma: A Systematic Review
Journal of Cancer Prevention
;
: 79-90, 2019.
Article
in English
| WPRIM
| ID: wpr-764306
ABSTRACT
Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to work in an unregulated manner that works together to push the cells into a cancerous state. With the discovery of non-coding RNAs such as microRNAs (miRNAs), it has been shown that a different layer of gene regulations may be disrupted which would cause cancer. This fact led scientists to put their focus on the role of miRNAs in cancer. A mature miRNA contains a seed sequence which gives the miRNA to identify and attach to the interest mRNA; this attachment may lead degradation of mRNA or suppress of translation of the mRNA. The expression of miRNAs in medulloblastoma shows that some of these non-coding RNAs are overexpressed (OncomiRs) which help cells to proliferate and keep their stemness features. On the other hand, there are other forms of these miRNAs which normally inhibit cell proliferation and promote cell differentiation (tumor suppressor). These are down-regulated during cancer progression. In this systematic review, we attempted to gather several important studies on miRNAs’ role in medulloblastoma tumors and the importance of these non-coding RNAs in the future study of cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Social Control, Formal
/
Brain Neoplasms
/
RNA, Messenger
/
Cell Differentiation
/
Mortality
/
Genes, Tumor Suppressor
/
RNA, Untranslated
/
MicroRNAs
/
Cell Proliferation
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Child
/
Humans
Language:
English
Journal:
Journal of Cancer Prevention
Year:
2019
Type:
Article
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