Language-Related White-Matter-Tract Deficits in Children with Benign Epilepsy with Centrotemporal Spikes: A Retrospective Study
Journal of Clinical Neurology
;
: 502-510, 2019.
Article
in English
| WPRIM
| ID: wpr-764366
ABSTRACT
BACKGROUND AND PURPOSE:
Benign epilepsy with centrotemporal spikes (BECTS) is one of the most common pediatric epilepsies, and it generally has a good prognosis. However, recent research has indicated that the epileptic activity of BECTS can cause cognitive defects such as language, visuospatial, and auditory verbal memory deficits. This study assessed language-delivery deficits in BECTS patients using diffusion-tensor magnetic resonance imaging (DTI).METHODS:
T1-weighted MRI, DTI, and language tests were conducted in 16 BECTS patients and 16 age-matched controls. DTI data were analyzed using the TRActs Constrained by Underlying Anatomy tool in FreeSurfer 5.3, and 18 major white-matter tracts were extracted, which included 4 language-related tracts the inferior longitudinal fasciculus, superior longitudinal fasciculus-parietal terminations, superior longitudinal fasciculus-temporal terminations, and uncinate fasciculus (UNC). Language tests included the Korean version of the Receptive and Expressive Vocabulary Test, Test of Problem-Solving Abilities (TOPS), and the mean length of utterance in words.RESULTS:
The BECTS group exhibited decreased mean fractional anisotropy and increased mean radial diffusivity, with significant differences in both the superior longitudinal fasciculus and the left UNC (p<0.05), which are the language-related white-matter tracts in the dual-loop model. The TOPS language test scores were significantly lower in the BECTS group than in the control group (p<0.05).CONCLUSIONS:
It appears that BECTS patients can exhibit language deficits. Seizure activities of BECTS could alter DTI scalar values in the language-related white-matter tracts.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Seizures
/
Magnetic Resonance Imaging
/
Retrospective Studies
/
Anisotropy
/
Cognition Disorders
/
Epilepsy, Rolandic
/
Epilepsy
/
Language Tests
/
Memory Disorders
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2019
Type:
Article
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