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First Korean case of factor V Leiden mutation in pregnant woman with a history of recurrent pregnancy loss
Journal of Genetic Medicine ; : 23-26, 2019.
Article in English | WPRIM | ID: wpr-764508
ABSTRACT
Thrombophilia refers to inherited or acquired hemostatic disorders that result in a predisposition to blood clot formation. When combined with the hypercoagulable state that is characteristic of pregnancy, there is an increased risk of severe and recurrent pregnancy complications. Activated protein C resistance caused by factor V Leiden (FVL) mutation is known to be the most common cause of inherited thrombophilia in Caucasian population. FVL mutation has been related to pregnancy complications associated with hypercoagulation, e.g. miscarriage, intrauterine fetal demise, placental abruption, and intrauterine growth retardation. Although the FVL mutation is easily detected using molecular DNA techniques, patients who are heterozygous for this disorder often remain asymptomatic until they develop a concurrent prothrombotic condition. Because there are potentially serious effects of FVL mutation for pregnancy, and because effective treatment strategies exist, early detection and treatment of this condition might be considered.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pregnancy Complications / DNA / Factor V / Abortion, Spontaneous / Thrombophilia / Hemostatic Disorders / Activated Protein C Resistance / Pregnant Women / Abruptio Placentae / Fetal Death Type of study: Screening study Limits: Female / Humans / Pregnancy Language: English Journal: Journal of Genetic Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pregnancy Complications / DNA / Factor V / Abortion, Spontaneous / Thrombophilia / Hemostatic Disorders / Activated Protein C Resistance / Pregnant Women / Abruptio Placentae / Fetal Death Type of study: Screening study Limits: Female / Humans / Pregnancy Language: English Journal: Journal of Genetic Medicine Year: 2019 Type: Article