Conservative hysteroscopic treatment of stage I well differentiated endometrial cancer in patients with high surgical risk: a pilot study / 부인종양
Journal of Gynecologic Oncology
;
: e62-2019.
Article
in English
| WPRIM
| ID: wpr-764521
ABSTRACT
OBJECTIVE:
To report hysteroscopic treatment combined with levonorgestrel-releasing intrauterine device (LNG-IUD) to treat women with early well differentiated endometrial cancer (EC) at high surgical risk.METHODS:
Nine women diagnosed with stage IA, grade 1 endometrioid EC which was contraindicated or refused standard treatment with external beam radiation therapy with or without brachytherapy were enrolled in our prospective study. Endo-myometrial hysteroscopic resection of the whole uterine cavity and the placement of LNG-IUD for 5 years was performed. Response rate, perioperative complications, and recurrence of disease were evaluated.RESULTS:
None had intra or post-operative complications and all were discharged no later than the third day of hospitalization. After 6 months from surgery, all the women showed a complete regression of the lesion. All the women completed the 5 years follow-up and in no case was detected sign of recurrence. Two women died for causes unrelated to the tumor or the ongoing therapy.CONCLUSION:
The alternative treatment with endo-myometrial hysteroscopic resection and LNG-IUD in women with stage IA, grade 1 endometrioid EC showed initial encouraging outcomes in terms of effectiveness and safety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Brachytherapy
/
Hysteroscopy
/
Pilot Projects
/
Prospective Studies
/
Follow-Up Studies
/
Endometrial Neoplasms
/
Hospitalization
/
Intrauterine Devices
/
Obesity
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2019
Type:
Article
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