Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)
Journal of Neurogastroenterology and Motility
;
: 395-401, 2011.
Article
in English
| WPRIM
| ID: wpr-76464
ABSTRACT
BACKGROUND/AIMS:
The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals.METHODS:
Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (beta version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test.RESULTS:
Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone.CONCLUSIONS:
This study showed that high-viscosity liquid meals delayed gastric emptying however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Benzamides
/
Breath Tests
/
Gastroesophageal Reflux
/
Morpholines
/
Fasting
/
Pectins
/
Cross-Over Studies
/
Meals
/
Gastric Emptying
Type of study:
Controlled clinical trial
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS