Polydeoxyribonucleotide, as a Novel Approach for the Management of Medication-Related Osteonecrosis of the Jaw: A Preliminary Observational Study
Journal of Korean Dental Science
;
: 57-61, 2018.
Article
in English
| WPRIM
| ID: wpr-764786
ABSTRACT
PURPOSE:
Polydeoxyribonucleotide (PDRN), consisting of a mixture of deoxyribonucleotide polymers, has been suggested to have anti-inflammatory effects and enhance angiogenesis as an adenosine A(2A) receptor agonist. The aim of this study was to report the effectiveness of PDRN as an adjuvant therapy after surgical debridement in MRONJ (medication-related osteonecrosis of the jaw) patients. MATERIALS ANDMETHODS:
Five patients (1 male, 4 females, age 65~79 years) who were diagnosed with MRONJ stage 2 or 3 underwent surgical debridement and PDRN mucosal injection. After surgical debridement, patients were subject to daily injection with 1 ml of PDRN around the surgical wound for 14 days.RESULT:
The patients' symptoms gradually disappeared. The surgical wound uneventfully healed, and no recurrence was observed during the follow-up period.CONCLUSION:
Although further studies are required, the present study first describes the possibility of PDRN as a useful option for MRONJ treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteonecrosis
/
Polymers
/
Recurrence
/
Wounds and Injuries
/
Follow-Up Studies
/
Debridement
/
Receptor, Adenosine A2A
/
Observational Study
/
Jaw
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Dental Science
Year:
2018
Type:
Article
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