Development of a Screening Algorithm for Alzheimer's Disease Using Categorical Fluency and Confrontational Naming Abilities
Journal of Korean Geriatric Psychiatry
;
: 28-32, 2019.
Article
in English
| WPRIM
| ID: wpr-764840
ABSTRACT
OBJECTIVE:
Declines in naming ability and semantic memory are well-known features of early Alzheimer's disease (AD). We developed a new screening algorithm for AD using two brief language tests the Categorical Fluency Test (CFT) and 15-item Boston Naming Test (BNT15).METHODS:
We administered the CFT, BNT15, and Mini-Mental State Examination (MMSE) to 150 AD patients with a Clinical Dementia Rating of 0.5 or 1 and to their age- and gender-matched cognitively normal controls. We developed a composite score for screening AD (LANGuage Composite score, LANG-C) that comprised demographic characteristics, BNT15 subindices, and CFT subindices. We compared the diagnostic accuracies of the LANG-C and MMSE using receiver operating curve analysis.RESULTS:
The LANG-C was calculated using the logit of test scores weighted by their coefficients from forward stepwise logistic regression models logit (case)=12.608−0.107×age+1.111×gender+0.089×education−0.314×HS(1st)−0.362×HS(2nd)+0.455×perseveration+1.329×HFCR(2nd)−0.489×MFCR(1st)−0.565×LFCR(3rd). The area under the curve of the LANG-C for diagnosing AD was good (0.894, 95% confidence interval=0.853–0.926 ; sensitivity=0.787, specificity=0.840), although it was smaller than that of the MMSE.CONCLUSION:
The LANG-C, which is easy to automate using PC or smart devices and to deliver widely via internet, can be a good alternative for screening AD to MMSE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Semantics
/
Logistic Models
/
Mass Screening
/
Internet
/
Dementia
/
Alzheimer Disease
/
Language Tests
/
Memory
Type of study:
Diagnostic study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
Language:
English
Journal:
Journal of Korean Geriatric Psychiatry
Year:
2019
Type:
Article
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