Efficacy of Afatinib in a Previously-Treated Patient with Non-Small Cell Lung Cancer Harboring HER2 Mutation: Case Report
Journal of Korean Medical Science
;
: e7-2018.
Article
in English
| WPRIM
| ID: wpr-764847
ABSTRACT
Human epidermal growth factor receptor 2 (HER2) mutation in non-small cell lung cancer (NSCLC) is an oncogenic driver that possibly becomes a druggable target to HER2-targeted therapy. The benefit of HER2-targeted therapy is much less defined especially in eastern populations. We provide evidence of clinical benefit of afatinib in a 50-year-old Asian woman with HER2-mutant NSCLC who previously failed cytotoxic chemotherapy and gefitinib treatment. Next-generation sequencing of the tumor tissue revealed a HER2 exon 20 mutation (c.2437A > G), which has never been reported. The patient was treated with afatinib for more than four months. She showed rapid radiologic response within a month, and maintained stable state until the last dose of afatinib.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Exons
/
Carcinoma, Non-Small-Cell Lung
/
Asian People
/
Drug Therapy
/
ErbB Receptors
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2018
Type:
Article
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