Effects of One-dose Varicella Vaccination on Disease Severity in Children during Outbreaks in Seoul, Korea
Journal of Korean Medical Science
;
: e83-2019.
Article
in English
| WPRIM
| ID: wpr-764924
ABSTRACT
BACKGROUND:
In Korea, the incidence of varicella has increased despite the introduction of a universal one-dose vaccination for children aged 12–15 months in 2005. A previous study demonstrated that the vaccine effectiveness was insufficient to prevent against varicella. We assessed the effect of the varicella vaccination on disease severity.METHODS:
Epidemiologic investigation of varicella cases in Seoul metropolitan area from 2015 to 2017 were used. Varicella-related symptoms such as rash were determined by the clinical practitioners. Disease severity of patients was assessed by the number of skin lesions and divided into mild (≤ 50) and moderate (51–249) to severe (≥ 250). Unconditional logistic regression analysis was performed and age was controlled.RESULTS:
Among a total of 1,008 varicella cases reported, 869 cases were breakthrough cases and 139 were unvaccinated cases. The risk for occurrence of moderate-to-severe disease in the breakthrough group was 0.57 times less than that of the unvaccinated group.CONCLUSION:
These data suggest that national varicella vaccination may have a significant effect on attenuation of disease severity in children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Logistic Models
/
Chickenpox
/
Incidence
/
Disease Outbreaks
/
Vaccination
/
Exanthema
/
Seoul
/
Korea
Type of study:
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2019
Type:
Article
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