Effect of Hyperglycemia on Myocardial Perfusion in Diabetic Porcine Models and Humans
Journal of Korean Medical Science
;
: e202-2019.
Article
in English
| WPRIM
| ID: wpr-765027
ABSTRACT
BACKGROUND:
Diabetes mellitus (DM) causes macro- and microvasculopathy, but data on cardiac microvascular changes in large animals are scarce. We sought to determine the effect of DM on macro- and microvascular changes in diabetic pigs and humans.METHODS:
Eight domestic pigs (4 with type I diabetes and 4 controls) underwent coronary angiography with optical coherence tomography (OCT; at baseline and 1 and 2 months), coronary computed tomography angiography, cardiac magnet resonance (CMR) imaging, and histologic examination.RESULTS:
The diabetic pigs had more irregular capillaries with acellular capillaries and a smaller capillary diameter (11.7 ± 0.33 μm vs. 13.5 ± 0.53 μm; P < 0.001) than those of the control pigs. The OCT showed no significant epicardial stenosis in either group; however diabetic pigs had a greater intima-media thickness. CMR results showed that diabetic pigs had a lower relative upslope at rest (31.3 ± 5.9 vs. 37.9 ± 8.1; P = 0.011) and during stress (18.0 ± 3.0 vs. 21.6 ± 2.8; P = 0.007) than the control pigs, implying decreased myocardial perfusion. Among the 79 patients with ST elevation myocardial infarction, 25 had diabetes and they had lower myocardial perfusion on CMR as well.CONCLUSION:
DM causes microvascular remodeling and a decrease in myocardial perfusion in large animals at a very early stage of the disease course. Early and effective interventions are necessary to interrupt the progression of vascular complications in diabetic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Swine
/
Capillaries
/
Angiography
/
Coronary Angiography
/
Constriction, Pathologic
/
Sus scrofa
/
Tomography, Optical Coherence
/
Diabetes Mellitus
/
Hyperglycemia
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2019
Type:
Article
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