The First Case of Para-Bombay Blood Type Encountered in a Korean Tertiary Hospital
Journal of Korean Medical Science
;
: e258-2019.
Article
in English
| WPRIM
| ID: wpr-765088
ABSTRACT
Para-Bombay phenotypes are rare blood groups that have inherent defects in producing H antigens associated with FUT1 and/or FUT2. We report the first case of para-Bombay blood type in a Southeast Asian patient admitted at a tertiary hospital in Korea. A 23-year-old Indonesian man presented to the hospital with fever and was diagnosed with a disseminated nontuberculous mycobacterium infection and anemia. During blood group typing for blood transfusion, cell typing showed no agglutination with both anti-A and anti-B reagents. Serum typing showed strong reactivity against B cells and trace agglutination pattern with A1 cells. His red blood cells failed to react with anti-H reagents. Direct sequencing of FUT1 and FUT2 revealed a missense variation, c.328G>A (p.Ala110Thr, rs56342683, FUT1*01W.02), and a synonymous variant, c.390C>T (p.Asn130=, rs281377, Se³⁵⁷), respectively. This highlights the need for both forward and reverse grouping.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Blood Group Antigens
/
Blood Transfusion
/
ABO Blood-Group System
/
B-Lymphocytes
/
Agglutination
/
Asian People
/
Erythrocytes
/
Fever
/
Tertiary Care Centers
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2019
Type:
Article
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